Saïd Kourrich

Professeur

Photo de Saïd Kourrich
Téléphone : (514) 987-3000 poste 6402
Local : SB-3405
Langues : Français, Anglais, Berbère
Informations générales

Cheminement académique

. Professeur régulier, Département des Sciences Biologiques, UQAM, Montréal, QC, Canada, 2018-auj

. Professeur en Psychiatrie, Département de Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA, 2013-2018

. Staff Scientist, National Institutes of Health/Johns Hopkins Bayview Medical Center, NIDA, Baltimore, MD, USA, 2010-2013

. Professeur Assistant de Recherche, Université du Minnesota, Minneapolis, MN, USA, 2008-2010

. Postdoctorat, Université du Minnesota, Minneapolis, MN, USA, 2005-2008

. Postdoctorat, Université Concordia, Montréal, Canada, 2002-2004

. Doctorat en Neuroscience, Université de Provence, Aix-Marseille I, Marseille, France, 1998-2001

. Diplôme d'Études Approfondies (DEA) en Neuroscience, Université de Provence, Aix-Marseille I, Marseille, France, 1998

. Maîtrise de Biologie Cellulaire et Physiologie, Université Louis Pasteur, Strasbourg, France, 1997

Projets de recherche en cours

  • Basic mechanisms regulating neuronal excitability and cognitive functions

    Natural Sciences and Engineering Research Council (Canada)

  • Action of psychostimulant drugs on neuronal intrinsic excitability and drug-seeking behavior

    National Institute on Drug Abuse - National Institutes of Health (USA)

Affiliations externes principales

  • Assistant Professor, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
Enseignement

Publications

Articles scientifiques
  • Delint-Ramirez, I., Garcia-Oscos, F., Segev, A. et Kourrich, S. (2018). Cocaine engages a non-canonical, dopamine-independent, mechanism that controls neuronal excitability in the nucleus accumbens. Molecular Psychiatry. http://dx.doi.org/10.1038/s41380-018-0092-7.
  • Segev, A., Yanagi, M., Scott, D., Southcott, S.A., Lister, J., Tan, C., Li, W., Birnbaum, S.G., Kourrich, S. et Tamminga, C. A. (2018). Reduced GluN1 in mouse dentate gyrus is associated with CA3 hyperactivity and psychosis-like behaviors. Molecular Psychiatry. http://dx.doi.org/10.1038/s41380-018-0124-3.
  • Yun, A., Reynolds, R.P., Rivera, P.D., Segev, A., Ito, N., Mukherjee, S., Richardson, D.R., Kang, C.E., Chetkovitch, D.M., Roth, B.L., Kourrich, S. et Eisch, A.J. (2018). Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive. Nature Medicine, 24(5), 658–666. http://dx.doi.org/10.1038/s41591-018-0002-1.
  • Mendoza, M.L., Anderson, E.M., Kourrich, S. et Eisch, A.J. (2016). A NAc for Spinal Adjustments After Cocaine or Stress. Biological Psychiatry, 79(11), 872–874. http://dx.doi.org/10.1016/j.biopsych.2016.04.013.
  • Segev, A., Garcia-Oscos, F. et Kourrich, S. (2016). Whole-Cell Patch-Clamp Recordings in Brain Slices. Journal of Visualized Experiments, (112), e54024. http://dx.doi.org/10.3791/54024.
  • Jedynak J, H.M., Ingebretson A, Ebner SR, Kelly M, Fischer RA, Kourrich S, Thomas MJ. (2015). Cocaine and Amphetamine Induce Overlapping but Distinct Patterns of AMPAR Plasticity in Nucleus Accumbens Medium Spiny Neurons. Neuropsychopharmacology. http://dx.doi.org/10.1038/npp.2015.168.
  • Kourrich, S., Calu, J.D. et Bonci, A. (2015). Intrinsic plasticity: an emerging player in addiction. Nature Reviews in Neuroscience, 16(3), 173–184. http://dx.doi.org/10.1038/nrn3877.
  • Larson, E.B., Wissman, A.M., Loriaux, A.L., Kourrich, S. et Self D.W. (2015). Optogenetic stimulation of accumbens shell or shell projections to lateral hypothalamus produces differential effects on the motivation for cocaine. Journal of Neuroscience, 35(8), 3537–3543. http://dx.doi.org/10.1523/JNEUROSCI.1524-14.2015.
  • Jayanthi, S., McCoy, M.T., Chen, B., Britt, J., Kourrich, S., Yau, H.J., Ladenheim, B., Krasnova, I.N., Bonci, A. et Cadet, J.L. (2014). Methamphetamine downregulates striatal glutamate receptors via diverse epigenetic mechanisms. Biological Psychiatry, 76(1), 47–56. http://dx.doi.org/10.1016/j.biopsych.2013.09.034.
  • Robison, A.J., Vialou, V., Mazei-Robison, M., Feng, J., Kourrich, S., Collins, M., Wee, S., Koob, G., Turecki, G., Neve, R., Thomas, M.J. et Nestler, E.J. (2013). Behavioral and Structural Responses to Chronic Cocaine Require a Feedforward loop involving ΔFosB and Calcium/Calmodulin-Dependent Protein Kinase II in the nucleus accumbens shell. Journal of Neuroscience, 33(10), 4295–4307. http://dx.doi.org/10.1523/JNEUROSCI.5192-12.2013.
  • Kumar, V., Kim, K., Joseph, C., Kourrich, S., Yoo, S.H., Huang, H.C., Vitaterna, M.H., Pardo-Manuel de Villena, F., Churchill, G., Bonci, A. et Takahashi J.S. (2013). C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response. Science, 342(6165), 1508–1512. http://dx.doi.org/10.1126/science.1245503.
  • Kourrich, S., Hayashi, T., Chuang, J.J., Tsai, S.Y., Su, T.P. et Bonci, A. (2013). Dynamic interaction between Sigma-1R and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell, 152(1-2), 236–247. http://dx.doi.org/10.1016/j.cell.2012.12.004.
  • Kourrich, S., Klug, J.R., Mayford, M. et Thomas, M.J. (2012). AMPAR-Independent Effect of striatal αCaMKII promotes the sensitization of cocaine reward. The Journal of Neuroscience, 32(19), 6578–6786. http://dx.doi.org/10.1523/JNEUROSCI.6391-11.2012.
  • Kourrich, S., Fujimoto, M., Su, T.P. et Bonci, A. (2012). The Sigma-1 receptors: roles in neuronal plasticity and disease. Trends in Neurosciences, 35(12), 762–771. http://dx.doi.org/10.1016/j.tins.2012.09.007.
  • Penrod, R.D., Kourrich, S., Kearney, E., Thomas, M.J. et Lanier, L.M. (2011). An embryonic culture system for the investigation of striatal medium spiny neuron dendritic spine development and plasticity. Journal of Neuroscience Methods, 200(1), 1–13. http://dx.doi.org/10.1016/j.jneumeth.2011.05.029.
  • Rothwell, P.E., Kourrich, S. et Thomas, M.J. (2011). Environmental novelty causes stress-like adaptations at nucleus accumbens synapses: Implications for studying addiction-related plasticity. Neuropharmacology, 61(7), 1152–1159. http://dx.doi.org/10.1016/j.neuropharm.2011.01.038.
  • Rothwell, P.E., Kourrich, S. et Thomas, M.J. (2011). Synaptic adaptations in the nucleus accumbens caused by experiences linked to relapse. Biological Psychiatry, 69(11), 1124–116. http://dx.doi.org/10.1016/j.biopsych.2010.12.028.
  • Arora, D., Haluk, D.M., Kourrich, S., Pravetoni, M., Fernández-Alacid, L., Nicolau, J.C., Luján, R. et Wickman, K. (2010). Altered neurotransmission in the mesolimbic reward system of Girk-/- mice. Journal of Neurochemistry, 114(5), 1487–1497. http://dx.doi.org/10.1111/j.1471-4159.2010.06864.x.
  • Xie, K., Allen, K.L., Kourrich, S., Colón-Saez, J., Thomas, M.J., Wickman, K. et Martemyanov, K.A. (2010). Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. Nature Neuroscience, 13(6), 661–663. http://dx.doi.org/10.1038/nn.2549.
  • Kourrich, S. et Thomas, M.J. (2009). Similar neurons, opposite adaptations: psychostimulant experience differentially alters firing properties in accumbens core versus shell. Journal of Neuroscience, 29(39), 12275–12283. http://dx.doi.org/10.1523/JNEUROSCI.3028-09.2009.
  • Ohtsuka, N., Tansky, M.F., Kuang, H., Kourrich, S., Thomas, M.J., Rubenstein, J.R., Ekker, M., Leeman, S.E. et Tsien J.Z. (2008). Functional disturbances in the striatum by region-specific ablation of NMDA receptors. PNAS, 105(35), 12961–12966. http://dx.doi.org/10.1073/pnas.0806180105.
  • Kourrich, S., Glasgow, S.D., Caruana, D.A. et Chapman, C.A. (2008). Postsynaptic signals mediating induction of long-term synaptic depression in the entorhinal cortex. Neural plasticity, 2008, Article ID 8403742008. http://dx.doi.org/10.1155/2008/840374.
  • Kourrich, S., Rothwell, P.E., Klug, J.R. et Thomas, M.J. (2007). Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens. Journal of Neuroscience, 27(30), 7921–7928. http://dx.doi.org/10.1523/JNEUROSCI.1859-07.2007.
  • Augustyniak, P.N., Kourrich, S., Rezazadeh, S.M., Stewart, J. et Arvanitogiannis, A. (2006). Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder. Behavioural Brain Research, 167(2), 379–382. http://dx.doi.org/10.1016/j.bbr.2005.09.014.
  • Kourrich, S., Manrique, C., Salin, P. et Mourre, C. (2005). Transient hippocampal down-regulation of Kv1.1 subunit mRNA during associative learning in rats. Learning & Memory, 12(5), 511–519. http://dx.doi.org/10.1101/lm.86305.
  • Kourrich, S., Masmejean, F., Martin-Eauclaire, M.-F., Soumireu-Mourat, B. et Mourre, C. (2003). Inwardly rectifying Kir3.1 subunit knockdown impairs learning and memory in an olfactory associative task in rat. Molecular Brain Research, 113(1-2), 97–106. http://dx.doi.org/10.1016/S0169-328X(03)00096-2.
  • Kourrich, S. et Chapman, C.A. (2003). NMDA receptor-dependent long-term synaptic depression in the entorhinal cortex in vitro. Journal of Neurophysiology, 89(4), 2112–2119. http://dx.doi.org/10.1152/jn.00714.2002.
  • Vacher, H., Romi-Lebrun, R., Mourre, C., Lebrun, B., Kourrich, S., Masmejean, F., Nakajima, T., Legros, C., Crest, M., Bougis, P.E. et Martin-Eauclaire, M.F. (2001). A new class of scorpion toxin binding sites related to an A-Type K+ channel: pharmacological characterization and localization in rat brain. FEBS Letters, 501(1), 31–36. http://dx.doi.org/10.1016/S0014-5793(01)02620-5.
  • Fournier, C., Kourrich, S., Soumireu-Mourat, B. et Mourre, C. (2001). Apamin improves reference memory but not procedural memory in rats by blocking small conductance Ca(2+)-activated K(+) channels in an olfactory discrimination task. Behavioural Brain Research, 121(1-2), 81–93. http://dx.doi.org/10.1016/S0166-4328(00)00387-9.
  • Kourrich, S., Mourre, C. et Soumireu-Mourat, B. (2001). Kaliotoxin, a Kv1.1 and Kv1.3 channel blocker, improves associative learning in rats. Behavioural Brain Research, 120(1), 35–46. http://dx.doi.org/10.1016/S0166-4328(00)00356-9.
Chapitres de livre
  • Kourrich, S. (2017). Sigma-1 Receptor and Neuronal Excitability. Dans F.J. Kim et G.W. Pasternak (dir.). Sigma Proteins: Evolution of the Concept of Sigma Receptors (p. 109–130). Berlin : Springer. Récupéré de http://dx.doi.org/10.1007/164_2017_8.
    Notes: collection Handbook of Experimental Pharmacology, vol. 244
  • Kourrich, S. et Bonci, A. (2013). Synaptic and Neural plasticity. Dans D. Charney, J. Buxbaum, P. Sklar et E. Nestler (dir.). Neurobiology of Mental Illness (4e éd., p. 64–75). Oxford, Royaume-Uni : Oxford University Press.

Département des sciences biologiques

Le Département des sciences biologiques de l’UQAM est l’un des départements les plus dynamiques au Canada, profitant d’un des plus haut taux de subventions de recherche. La plupart de ses chercheurs sont regroupés au sein d’équipes de recherche de pointe en écologie, santé environnementale et toxicologie, et biotechnologies.

Coordonnées

Département des sciences biologiques
Local SB-R860
141, Avenue du Président-Kennedy
Montréal (Québec) H2X 1Y4