Diana Alison Averill

Diana Alison Averill

Département des sciences biologiques

Poste : Professeure

Courriel : averill.diana_alison@uqam.ca

Téléphone : (514) 987-3000 poste 4811

Local : SB-3455

Domaines d'expertise

  • Cancer / Traitement
  • Chimiothérapie / Hyperthermie
  • Radicaux libres / Antioxydants
  • Maladie d'Alzheimer
  • Toxicologie
Informations générales

Unités de recherche

  • Centre de recherche en toxicologie de l'environnement (TOXEN)
Enseignement et supervision
Publications

Grondin, M., Robinson, I., Do Carmo, S., et al. (2013). Cryopreservation of insulin-secreting INS832/13 cells using a wheat protein formulation. Cryobiology, 66(2), 136–143. http://dx.doi.org/10.1016/j.cryobiol.2012.12.008.


Pallepati, P. et Averill-Bates, D.A. (2011). Activation of ER stress and apoptosis by hydrogen peroxide in HeLa cells: Protective role of mild heat preconditioning at 40°C. Biochimica et Biophysica Acta – Molecular Cell Research, 1813(12), 1987–1999. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/j.bbamcr.2011.07.021.
Notes: doi: 10.1016/j.bbamcr.2011.07.021

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Pallepati, P. et Averill-Bates, D.A. (2011). Mild thermotolerance induced at 40 °c protects HeLa cells against activation of death receptor-mediated apoptosis by hydrogen peroxide. Free Radical Biology and Medicine, 50(6), 667–679. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/j.freeradbiomed.2010.11.022.
Notes: doi: 10.1016/j.freeradbiomed.2010.11.022

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Roy, J., Pallepati, P., Bettaieb, A. et Averill-Bates, D.A. (2010). Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: Role of p53. Canadian Journal of Physiology and Pharmacology, 88(3), 353–368. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1139/Y09-134.
Notes: doi: 10.1139/Y09-134

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Pallepati, P. et Averill-Bates, D. (2010). Mild thermotolerance induced at 40 °C increases antioxidants and protects HeLa cells against mitochondrial apoptosis induced by hydrogen peroxide: Role of p53. Archives of Biochemistry and Biophysics, 495(2), 97–111. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/j.abb.2009.12.014.
Notes: doi: 10.1016/j.abb.2009.12.014

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Roy, J., Pallepati, P., Bettaieb, A., Tanel, A. et Averill-Bates, D.A. (2009). Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells. Chemico-Biological Interactions, 181(2), 154–167. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/j.cbi.2009.07.001.
Notes: doi: 10.1016/j.cbi.2009.07.001

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Grondin, M., Hamel, F., Averill-Bates, D.A. et Sarhan, F. (2009). Wheat proteins enhance stability and function of adhesion molecules in cryopreserved hepatocytes. Cell Transplantation, 18(1), 79–88. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.3727/096368909788237104.
Notes: doi: 10.3727/096368909788237104

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Grondin, M., Hamel, F., Averill-Bates, D.A. et Sarhan, F. (2009). Wheat proteins improve cryopreservation of rat hepatocytes. Biotechnology and Bioengineering, 103(3), 582–591. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1002/bit.22270.
Notes: doi: 10.1002/bit.22270

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Haidara, K., Marion, M., Gascon-Barré, M., Denizeau, F. et Averill-Bates, D.A. (2008). Implication of caspases and subcellular compartments in tert-butylhydroperoxide induced apoptosis. Toxicology and Applied Pharmacology, 229(1), 65–76. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/j.taap.2008.01.010.
Notes: doi: 10.1016/j.taap.2008.01.010

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Averill-Bates, D.A., Ke, Q., Tanel, A., Roy, J., Fortier, G. et Agostinelli, E. (2008). Mechanism of cell death induced by spermine and amine oxidase in mouse melanoma cells. International Journal of Oncology, 32(1), 79–88.

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Grondin, M., Hamel, F., Sarhan, F. et Averill-Bates, D.A. (2008). Metabolic activity of cytochrome P450 isoforms in hepatocytes cryopreserved with wheat protein extract. Drug Metabolism and Disposition, 36(10), 2121–2129. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1124/dmd.108.021162.
Notes: doi: 10.1124/dmd.108.021162

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Wrzal, P.K., Bettaieb, A. et Averill-Bates, D.A. (2008). Molecular mechanisms of apoptosis activation by heat shock in multidrug-resistant Chinese hamster cells. Radiation Research, 170(4), 498–511. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1667/RR1214.1.
Notes: doi: 10.1667/RR1214.1

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Bettaieb, A. et Averill-Bates, D.A. (2008). Thermotolerance induced at a fever temperature of 40°C protects cells against hyperthermia-induced apoptosis mediated by death receptor signalling. Biochemistry and Cell Biology, 86(6), 521–538. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1139/O08-136.
Notes: doi: 10.1139/O08-136

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Tanel, A. et Averill-Bates, D.A. (2007). Activation of the death receptor pathway of apoptosis by the aldehyde acrolein. Free Radical Biology and Medicine, 42(6), 798–810. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/j.freeradbiomed.2006.12.009.
Notes: doi: 10.1016/j.freeradbiomed.2006.12.009

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Tanel, A. et Averill-Bates, D.A. (2007). Inhibition of acrolein-induced apoptosis by the antioxidant N-acetylcysteine. Journal of Pharmacology and Experimental Therapeutics, 321(1), 73–83. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1124/jpet.106.114678.
Notes: doi: 10.1124/jpet.106.114678

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Tanel, A. et Averill-Bates, D.A. (2007). P38 and ERK mitogen-activated protein kinases mediate acrolein-induced apoptosis in Chinese hamster ovary cells. Cellular Signalling, 19(5), 968–977. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/j.cellsig.2006.10.014.
Notes: doi: 10.1016/j.cellsig.2006.10.014

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Okoumassoun, L., Averill-Bates, D., Denizeau, F. et Henderson, J.E. (2007). Parathyroid hormone related protein (PTHrP) inhibits TNFα-induced apoptosis by blocking the extrinsic and intrinsic pathways. Journal of Cellular Physiology, 210(2), 507–516. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1002/jcp.20892.
Notes: doi: 10.1002/jcp.20892

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Okoumassoun, L.E., Russo, C., Denizeau, F., Averill-Bates, D. et Henderson, J.E. (2007). Parathyroid Hormone-related Protein (PTHrP) inhibits mitochondrial- dependent apoptosis through CK2. Journal of Cellular Physiology, 212(3), 591–599. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1002/jcp.21055.
Notes: doi: 10.1002/jcp.21055

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Grondin, M., Marion, M., Denizeau, F. et Averill-Bates, D.A. (2007). Tributyltin induces apoptotic signaling in hepatocytes through pathways involving the endoplasmic reticulum and mitochondria. Toxicology and Applied Pharmacology, 222(1), 57–68. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/j.taap.2007.03.028.
Notes: doi: 10.1016/j.taap.2007.03.028

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Hamel, F., Grondin, M., Denizeau, F., Averill-Bates, D.A. et Sarhan, F. (2006). Wheat extracts as an efficient cryoprotective agent for primary cultures of rat hepatocytes. Biotechnology and Bioengineering, 95(4), 661–670. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1002/bit.20953.
Notes: doi: 10.1002/bit.20953

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Averill-Bates, D.A., Chérif, A., Agostinelli, E., Tanel, A. et Fortier, G. (2005). Anti-tumoral effect of native and immobilized bovine serum amine oxidase in a mouse melanoma model. Biochemical Pharmacology, 69(12), 1693–1704. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/j.bcp.2005.02.025.
Notes: doi: 10.1016/j.bcp.2005.02.025

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Tanel, A. et Averill-Bates, D.A. (2005). The aldehyde acrolein induces apoptosis via activation of the mitochondrial pathway. Biochimica et Biophysica Acta – Molecular Cell Research, 1743(3), 255–267. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/j.bbamcr.2004.11.007.
Notes: doi: 10.1016/j.bbamcr.2004.11.007

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Bettaieb, A. et Averill-Bates, D.A. (2005). Thermotolerance induced at a mild temperature of 40°C protects cells against heat shock-induced apoptosis. Journal of Cellular Physiology, 205(1), 47–57. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1002/jcp.20386.
Notes: doi: 10.1002/jcp.20386

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Jurkiewicz, M., Averill-Bates, D.A., Marion, M. et Denizeau, F. (2004). Involvement of mitochondrial and death receptor pathways in tributyltin-induced apoptosis in rat hepatocytes. Biochimica et Biophysica Acta – Molecular Cell Research, 1693(1), 15–27. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/j.bbamcr.2004.04.001.
Notes: doi: 10.1016/j.bbamcr.2004.04.001

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Souslova, T. et Averill-Bates, D.A. (2004). Multidrug-resistant hela cells overexpressing MRP1 exhibit sensitivity to cell killing by hyperthermia: Interactions with etoposide. International Journal of Radiation Oncology Biology Physics, 60(5), 1538–1551. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/j.ijrobp.2004.07.686.
Notes: doi: 10.1016/j.ijrobp.2004.07.686

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Saavedra, Y.G.L., Mateescu, M.A., Averill-Bates, D.A. et Denizeau, F. (2003). Polyvinylalcohol three-dimensional matrices for improved long-term dynamic culture of hepatocytes. Journal of Biomedical Materials Research – Part A, 66(3), 562–570.

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Okoumassoun, L.-E., Averill-Bates, D., Marion, M. et Denizeau, F. (2003). Possible mechanisms underlying the mitogenic action of heptachlor in rat hepatocytes. Toxicology and Applied Pharmacology, 193(3), 356–369. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/j.taap.2003.07.010.
Notes: doi: 10.1016/j.taap.2003.07.010

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Okoumassoun, L.-E., Averill-Bates, D., Gagné, F., Marion, M. et Denizeau, F. (2002). Assessing the estrogenic potential of organochlorine pesticides in primary cultures of male rainbow trout (Oncorhynchus mykiss) hepatocytes using vitellogenin as a biomarker. Toxicology, 178(3), 193–207. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/S0300-483X(02)00228-7.
Notes: doi: 10.1016/S0300-483X(02)00228-7

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Lord-Fontaine, S. et Averill-Bates, D.A. (2002). Heat shock inactivates cellular antioxidant defenses against hydrogen peroxide: Protection by glucose. Free Radical Biology and Medicine, 32(8), 752–765. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/S0891-5849(02)00769-4.
Notes: doi: 10.1016/S0891-5849(02)00769-4

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Okoumassoun, L.-E., Brochu, C., Deblois, C., et al. (2002). Vitellogenin in tilapia male fishes exposed to organochlorine pesticides in Ouémé River in Republic of Benin. Science of the Total Environment, 299(1-3), 163–172. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/S0048-9697(01)01053-1.
Notes: doi: 10.1016/S0048-9697(01)01053-1

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Lord-Fontaine, S., Agostinelli, E., Przybytkowski, E. et Averill-Bates, D.A. (2001). Amine oxidase, spermine, and hyperthermia induce cytotoxicity in P-glycoprotein overexpressing multidrug resistant Chinese hamster ovary cells. Biochemistry and Cell Biology, 79(2), 165–175. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1139/bcb-79-2-165.
Notes: doi: 10.1139/bcb-79-2-165

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Demers, N., Agostinelli, E., Averill-Bates, D.A. et Fortier, G. (2001). Immobilization of native and poly(ethylene glycol)-treated ('PEGylated') bovine serum amine oxidase into a biocompatible hydrogel. Biotechnology and Applied Biochemistry, 33(3), 201–207. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1042/BA20010009.
Notes: doi: 10.1042/BA20010009

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Turcotte, S. et Averill-Bates, D.A. (2001). Sensitization to the cytotoxicity of melphalan by ethacrynic acid and hyperthermia in drug-sensitive and multidrug-resistant chinese hamster ovary cells. Radiation Research, 156(3), 272–282.

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Demeule, M., Laplante, A., Sepehr-Araé, A., et al. (1999). Inhibition of P-glycoprotein by cyclosporin A analogues and metabolites. Biochemistry and Cell Biology, 77(1), 47–58. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1139/bcb-77-1-47.
Notes: doi: 10.1139/bcb-77-1-47

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Przybytkowski, E. et Averill-Bates, D.A. (1996). Correlation between glutathione and stimulation of the pentose phosphate cycle in situ in Chinese hamster ovary cells exposed to hydrogen peroxide. Archives of Biochemistry and Biophysics, 325(1), 91–98. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1006/abbi.1996.0011.
Notes: doi: 10.1006/abbi.1996.0011

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Agostinelli, E., Przybytkowski, E. et Averill-Bates, D.A. (1996). Glucose, glutathione, and cellular response to spermine oxidation products. Free Radical Biology and Medicine, 20(5), 649–656. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/0891-5849(95)02149-3.
Notes: doi: 10.1016/0891-5849(95)02149-3

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Demeule, M., Vachon, V., Delisle, M.-C., et al. (1995). Molecular study of p-glycoprotein in multidrug resistance using surface plasmon resonance. Analytical Biochemistry, 230(2), 239–247. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1006/abio.1995.1469.
Notes: doi: 10.1006/abio.1995.1469

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Beaulieu, E., Demeule, M., Pouliot, J.-F., Averill-Bates, D.A., Murphy, G.F. et Beliveau, R. (1995). P-glycoprotein of blood brain barrier: Cross-reactivity of MAb C219 with a 190 kDa protein in bovine and rat isolated brain capillaries. Biochimica et Biophysica Acta – Biomembranes, 1233(1), 27–32. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/0005-2736(94)00239-L.
Notes: doi: 10.1016/0005-2736(94)00239-L

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Averill-Bates, D.A. et Courtemanche, B. (1995). The effect of hyperthermia and verapamil on melphalan cytotoxicity and transport in multidrug-resistant Chinese hamster ovary cells. Radiation Research, 143(1), 17–25. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.2307/3578921.
Notes: doi: 10.2307/3578921

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Averill-Bates, D.A., Agostinelli, E., Przybytkowski, E. et Mondovi, B. (1994). Aldehyde dehydrogenase and cytotoxicity of purified bovine serum amine oxidase and spermine in Chinese hamster ovary cells. Biochemistry and cell biology = Biochimie et biologie cellulaire, 72(1-2), 36–42.

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Agostinelli, E., Przybytkowski, E., Mondovi, B. et Averill-Bates, D.A. (1994). Heat enhancement of cytotoxicity induced by oxidation products of spermine in Chinese hamster ovary cells. Biochemical Pharmacology, 48(6), 1181–1186. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1016/0006-2952(94)90155-4.
Notes: doi: 10.1016/0006-2952(94)90155-4

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Averill-Bates, D.A. et Przybytkowski, E. (1994). The role of glucose in cellular defences against cytotoxicity of hydrogen peroxide in Chinese hamster ovary cells. Archives of Biochemistry and Biophysics, 312(1), 52–58. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1006/abbi.1994.1279.
Notes: doi: 10.1006/abbi.1994.1279

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Averill-Bates, D.A., Agostinelli, E., Przybytkowski, E., Mateescu, M.A. et Mondovi, B. (1993). Cytotoxicity and kinetic analysis of purified bovine serum amine oxidase in the presence of spermine in Chinese hamster ovary cells. Archives of Biochemistry and Biophysics, 300(1), 75–79. http://proxy.bibliotheques.uqam.ca/login?url=http://dx.doi.org/10.1006/abbi.1993.1011.
Notes: doi: 10.1006/abbi.1993.1011

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Intérêts de recherche

Département des sciences biologiques

Le Département des sciences biologiques de l’UQAM est l’un des départements les plus dynamiques au Canada, profitant d’un des plus haut taux de subventions de recherche. La plupart de ses chercheurs sont regroupés au sein d’équipes de recherche de pointe en écologie, santé environnementale et toxicologie, et biotechnologies.

Coordonnées

Département des sciences biologiques
Local SB-R860
141, Avenue du Président-Kennedy
Montréal (Québec) H2X 1Y4